To Drive
する verb
A thing that carries rotations (think wheels!) is most kinds of vehicles. So, it's kind of like saying you're "doing vehicles" here... but that doesn't make sense. What do you do to vehicles though? You drive them. That's why this word means to drive.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.
自転車を運転する
to drive a bicycle
車を運転する
to drive a car
トラックを運転する
to drive a truck
父は毎日、会社と家の間を車かバイクで運転する。
My father drives his car or motorcycle every day between his company and home.
私は休日しか運転しません。
I only drive on my days off.
船を運転するライセンスは持ってますか？
Do you have a license to steer a ship?