Burden
Responsibility
noun, verbal noun
You lose. Because of that, you have to carry this burden and responsibility.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.
私、これ以上あなたに負担をかけたくないんです。
I don't want to burden you any further.
この仕事は、経験の浅い社員には負担が大きいかもしれません。
This task may be burdensome for inexperienced employees.
10キロのお米を持ち上げることは、彼の腰の負担となった。
Lifting 10kg of rice was a burden on his lower back.
あんな男の借金を負担してあげるなんて、あなたの気が知れないわ。
I can't understand why you would take on the debts of a man like him.