Exhaustion
Impoverishment
noun, verbal noun
If you're tired by all the evil things in your life you might die of exhaustion!
While 疲労 and 疲れ mostly refer to physical or mental fatigue, 疲弊 describes being depleted and exhausted due to prolonged stress, overwork, or long-term difficulties. As a result, it can also be used to describe economic or financial exhaustion.
This is a jukugo word that uses the on'yomi readings of the kanji. You should be able to read this on your own.
人口が増えない限り、地方経済の疲弊が回復することはないでしょう。
It seems that the local economy will not recover from impoverishment unless the population increases.