Tiredness
Fatigue
noun
疲れる is "to get tired." This is the noun version, which makes it tiredness or fatigue.
疲れ is a more casual version of 疲労, so people commonly choose 疲れ over 疲労 in everyday conversation.
The reading comes from 疲れる.
お疲れ
good work (set phrase), fatigue (honorific)
疲れがとれる
fatigue is relieved
疲れがたまる
fatigue accumulates
疲れがとれない
unable to shake off fatigue
疲れが出る
fatigue sets in, fatigue shows
疲れを知らない
to be tireless
疲れをとる
to get rid of fatigue
疲れを感じる
to feel tired
疲れをいやす
to relieve fatigue
ネコは疲れをいやしてくれるよ。
Cats will soothe you when you're tired.
年のせいか、疲れが中々とれないんだよね。
Maybe it's because I'm old, but I can't shake off my fatigue easily.
うちの子は、疲れ知らずで、一日中ずーっと走り回ってられるんです。
Our little boy is tireless and can run around all day long.