Handmade
Homemade
noun, の adjective
When something is hand made, it is handmade!
The readings for these kanji are the kun'yomi readings. Just think of this word as two separate words put together (手 and 作る). The る in 作る gets changed to り because it's an adjective, and the つ in つくり gets changed to づ because of the way the words are combined with each other. You should know most of the reading that is in this word, though it will probably take a little bit of thinking to sort out the little changes in those readings.
このテーブルは、林さんの手作りです。
This table was handmade by Hayashi.
友人が手作りのプレゼントをくれました。
A friend gave me a handmade gift.
このレストランでは手作りのパスタが人気です。
Handmade pasta is popular in this restaurant.