Unpleasant
Uncomfortable
noun, な adjective
Things that are not pleasant are unpleasant or uncomfortable.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.
上司の不快なジョークに笑いたくもないのに笑っている自分が嫌いです。
I don’t want to laugh at my boss’s unpleasant jokes and I hate myself when I do.