Amulet
Charm
noun
You know how 守る is "to protect," right? This is like that, but it's the noun version. It's not really "a protection," though it kind of is. What things can you wear to protect you from things like bad luck, demons, and ancient aliens? That would be an amulet or a charm. You'll see these kinds of things sold at temples and such.
The reading is like that of 守る, so if you know the reading of that word you should be able to read this one as well.
このお守り、どこで買ったの？
Where did you buy this charm?
私はいつも父の写真をお守り代わりにサイフに入れています。
I always keep a picture of my father in my wallet as a talisman.
神様にも相性があるから、たくさんのお守りを同時に付けるのは、良くないんだって。
Apparently, even God has compatibility, so it's not good to wear multiple charms at the same time.